Would you like to learn how to use the brand-new IMPRES-M methodology to estimate PK models “without the model”? Come join us for this 1.5-day workshop where you will learn about the theory behind the impulse-response framework, and where you will get hands-on experience on how to use it.

Workshop description
Population PK modeling is a major interest within the PAGE community. With IMPRES-M, we have proudly established a new approach to describe pharmacokinetic (PK) and pharmacodynamic (PD) curves by smoothing rather than modeling based on differential-equations. This is achieved in a framework that allows for simulation and extrapolation much the same way as modelers in the field are used to. You therefore can be more time-efficient in your modeling workflows by circumventing the laborious model-building step!
In this workshop you will be presented with the theory behind IMPRES-M, and you will also get some hands-on experience fitting to data with IMPRES-M, either your own datasets or one provided by us. We will start off with the general smoothing practice, followed by its application to single-subject PK curves, population modeling, and eventually PK-PD. Furthermore, we will present extensions that are under development so you will also get to know where we will be heading next!

Learning objectives:
* Smoothing with P-splines: theory and practice (useful tool, widely applicable)
* IMPRES-M theory for PK modeling
* Hands-on single-subject PK modeling with IMPRES-M
* Non-traditional population estimation (mixed effects) approaches
* Hands-on population PK modeling with IMPRES-M
* Hands-on PK-PD modeling with IMPRES-M
* Ongoing research on IMPRES-M extensions

Target Audience
The target audience are PK or PK-PD modelers at beginner to advanced levels, who would like to extend their modeling toolkit.

Prerequisites
Attendees need to bring their own laptop with a recent version of R and Rstudio installed. Instructions to install IMPRES-M as an R package will be provided beforehand.

Instructors
Workshop host: Jeroen Elassaiss-Schaap
Workshop tutors: Vincenzo d’Iorio, Lorenzo Cifelli, Csaba Katai and Jie Ju